Response to Hu, Yang, and Sun

Pedro Nascimento de Lima; Carolyn M Rutter; Rosita Van Den Puttelaar; Anne I Hahn; Jonathan Ozik; Nicholson Collier; Ann G Zauber; Iris Lansdorp-Vogelaar; John M Inadomi

Abstract

This response addresses concerns about blood-based colorectal cancer screening, emphasizing that while such tests might increase initial adherence, they would reduce screening benefit by 34% to 50% and net monetary benefit by 50% to 70% compared to existing methods. The authors highlight that sensitivity to precursor lesions is crucial for cancer prevention, and current blood tests do not meet the effectiveness standards of colonoscopy or fecal immunochemical tests. They conclude that higher test adherence cannot compensate for poor test performance, and more research is needed on real-world screening behaviors before widespread adoption of blood-based screening.

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Citation

@article{nascimento_de_lima_response_2024,
	title = {Response to {Hu}, {Yang}, and {Sun}},
	copyright = {https://academic.oup.com/pages/standard-publication-reuse-rights},
	issn = {0027-8874, 1460-2105},
	url = {https://academic.oup.com/jnci/advance-article/doi/10.1093/jnci/djae341/7932130},
	doi = {10.1093/jnci/djae341},
	language = {en},
	urldate = {2025-01-17},
	journal = {JNCI: Journal of the National Cancer Institute},
	author = {Pedro {Nascimento de Lima} and Rutter, Carolyn M and Van Den Puttelaar, Rosita and Hahn, Anne I and Ozik, Jonathan and Collier, Nicholson and Zauber, Ann G and Lansdorp-Vogelaar, Iris and Inadomi, John M},
	month = dec,
	year = {2024},
	pages = {djae341}
}